Food Allergy and Gut Microbiota Dysfunction—Reply

Дата публикации: 01-08-2026 00:00:00

In Reply We thank McCarthy et al for their interest in our systematic review and meta-analysis addressing risk factors for the development of food allergy in early life. Consistent with our proposed multifactorial model of risk factors for food allergy, we agree that the microbiome deserves further study. We will address the effects of interventions and their certainty to prevent the development of food allergy in an ongoing systematic review, analogous to our recent work addressing atopic dermatitis (eczema). We agree with the correspondents’ sentiment that large, robust randomized clinical trials of microbiome-based interventions, including those suggested by the correspondents, and interventions modifying the other credible risk factors identified in our systematic review, are needed. Improving the funding and efficiency of conducting randomized clinical trials addressing allergy, enhancing the culture of contributing to randomized clinical trials by all stakeholders, and delivering unbiased definitive clinical trial results, either positive or negative, is crucial for driving transformative advances in the science of allergy, patient and family–important outcomes, population health, and society.

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