Dietary exposures and risk of anxiety and depression symptoms in the Lothian Birth Cohort 1936: a cohort-level GLAD Project analysis [version 2; peer review: 1 approved]

Дата публикации: 23-09-2026 05:01:36

Background Mental disorders such as anxiety and depression are leading contributors to disability worldwide, with growing concern in older adults—particularly in Scotland—where poor diet and mental health challenges are common. While the Global Burden of Disease (GBD) study has identified dietary risk factors for physical health, their associations with mental health in later life remain underexplored. Methods We used data from 880 participants (mean age 70y) of the Lothian Birth Cohort 1936 in Scotland to examine cross-sectional associations between 11 GBD-defined dietary exposures (fruit, vegetables, legumes, wholegrains, milk, fibre, calcium, polyunsaturated fatty acids, red meat, processed meat, sugar-sweetened beverages) and symptoms of anxiety and depression. Analyses followed harmonised protocols from the Global burden of disease Lifestyle And mental Disorders (GLAD) project (DERR2–10.2196/65576). Dietary exposures were standardised (g/day or % kcal/day), and mental health symptoms dichotomised using the Hospital Anxiety and Depression Scale (HADS ≥8 vs

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