There’s an important conversation happening in the world of heart health, one that directly impacts women.

For too long, women have been underdiagnosed, underrepresented, and underserved in cardiovascular research, but that is beginning to change. A new clinical trial, TRITON-CM, offers a powerful example of what happens when researchers listen to patients, to clinicians, and apply emerging scientific insights to better reflect biological differences between women and men.

At WomenHeart, we believe that better research leads to better care. And better care starts with inclusion.

Here’s what women should know.

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a serious condition where a protein builds up in the heart, causing it to stiffen and function less effectively. This can lead to symptoms like fatigue and shortness of breath, and to cardiomyopathy, which can cause heart failure and even death.

Historically, ATTR-CM has been considered a condition that primarily affects men, but emerging research and patient experiences tell a different story.

Women are often:

• Diagnosed later
• Misdiagnosed or overlooked
• Underrepresented in clinical trials

This gap matters. When women aren’t adequately included in research, treatments may not fully reflect how diseases show up in their bodies.

The TRITON-CM clinical trial is part of a growing effort to change that narrative.

What makes this trial different isn’t just its size; it’s how it was designed.

Researchers took intentional steps to:

• Include a broader and more diverse group of participants
• Adjust eligibility criteria to better reflect biological differences between women and men
• Incorporate direct feedback from patients and advocacy communities

This approach reflects an important shift in healthcare: designing research with patients, not just for them.

One of the most significant changes in TRITON-CM addresses a subtle but critical issue: how heart disease is measured.

Women naturally tend to have smaller hearts than men. In ATTR-CM, one key diagnostic marker is thickening of the heart wall. Using the same measurement threshold for both men and women may unintentionally exclude women, even when the disease is present.

This trial adjusts those criteria, helping ensure more women are accurately identified and included.

It’s a powerful reminder that equity in healthcare isn’t just about access; it’s about recognizing differences and designing accordingly.

Another standout feature of TRITON-CM is how deeply patient voices shaped the study.

Before launching, researchers:

• Spoke directly with patients
• Partnered with advocacy organizations
• Reviewed trial materials through a patient-centered lens

As a result, the trial was designed to:

• Reduce unnecessary burdens on participants
• Improve clarity in communication
• Create a more supportive experience throughout the process

This kind of collaboration leads to research that is not only scientifically rigorous but also more humane and accessible.

For many women, the journey to a heart disease diagnosis is not straightforward. Symptoms may be dismissed. Care may be delayed. And navigating multiple providers can feel overwhelming. That’s why awareness and education are critical.

Efforts include partnerships with advocacy organizations, which are helping to:

• Increase recognition of ATTR-CM symptoms
• Encourage earlier conversations with healthcare providers
• Highlight the importance of clinical trial participation

At WomenHeart, we know that knowledge is power, and that informed patients are stronger advocates for their own care.

TRITON-CM represents more than a single clinical trial. It reflects a broader movement toward equity in research and care.

For women, this means:

• Greater visibility in cardiovascular research
• More accurate diagnoses
• Treatments that better reflect lived experiences

Progress doesn’t happen automatically. It happens when women ask questions, share their stories, and demand to be seen.

If you or someone you love is living with heart disease, here are steps you can take:

Learn the signs: Don’t ignore symptoms like fatigue, swelling, or shortness of breath

Ask questions: If something feels off, trust your instincts and advocate for further evaluation

Explore clinical trials: Participation helps advance research for future generations of women

Connect with community: WomenHeart Champions, support networks, and connections through the SisterMatch app are here for you.

💬 You are not alone—and your voice matters.

At WomenHeart, we are committed to ensuring that every woman receives equitable, evidence-based, and compassionate heart care.

Explore our resources, connect with support, and learn how you can advocate for yourself and others. Together, we can shape a future where every woman is seen, heard, and represented in heart health research.