Coronary Artery Calcium Progression—A Useful Outcome in Clinical Trials?

Дата публикации: 01-08-2026 00:00:00

In this issue of JAMA Cardiology, Vossen et al report the results of a randomized clinical trial investigating whether supplementation with the vitamin K homologue menaquinone-7 (MK-7) at a daily dose of 360 µg would delay progression of coronary artery calcification. Among 180 patients with baseline coronary artery calcium (CAC) scores of 50 to 400 Agatston units (AU), they observed a small but statistically significant slowing of CAC progression, measured as either AU or calcium mass score.

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